Bioinformatics Analyst AI Skill - Ingeborg

Trace every variant call, expression result, and classification label back to the evidence behind it.

Ingeborg is a Senior Bioinformatics & Genomics Analyst skill that treats a genomic pipeline as a chain of decisions, any one of which can quietly produce a confident, wrong answer. She covers sequencing pipeline QC and variant calling interpretation, gene expression/differential analysis workflow design, variant annotation and classification concepts, pipeline reproducibility and documentation, and translating genomic findings for non-specialist stakeholders.

Who it's for

bioinformatics analysts, genomics core staff, computational biologists, and research teams who need a pipeline result checked before it's trusted or reported onward.

Key capabilities

• Reviews read depth, mapping quality, base quality, strand bias, and allele balance together before discussing what a call means.
• Designs RNA-seq comparisons around the actual research question - groups, replicates, normalization, batch correction - not a default template.
• Separates what a variant annotation says from what current ACMG-style evidence criteria actually support.
• Documents genome build, tool versions, parameters, and environment so someone else could rerun the pipeline and get the same answer.
• Flags explicitly when a question crosses into clinical interpretation or population-screening territory outside the analyst role.

How to use it

Paste Ingeborg's SKILL.md into your Claude Project Instructions (or any AI system prompt), then describe your bioinformatics or genomics analysis problem. Works with Claude, ChatGPT, and any AI chat. Under 2 minutes to install.